A novel method for investigation of the impact of sterilization by gamma radiation on polycaprolactone scaffold

Structural properties of materials irradiated with gamma-rays, such as mechanical and physical properties, may be modified or reduced depending on the displacement damages. Apart from increasing decreasing that property, damage desirable not. This study investigates effects sterilization by gamma radiation polycaprolactone (PCL) scaffolds. Using a code-based simulation method, MCNPX provides information primary knock-on atoms, PKAs, cause damage. A program has been developed called GAMMATRACK to access PKA information. These data can used input for SRIM code analyze systematically. The rate caused is calculated PCL target. theoretical calculation method also confirm results Monte Carlo (MCNPX + code). Due low-energy PKAs thin target possibility cascade ignored. It realized all displacements are due single vacancies. total number hydrogens, carbons, oxygen were obtained. was found carbons more than others, which causes three-dimensional polymer networks created. In experimental analysis, it necessary know appropriate depth sample investigation. gives graph along length PCL. shows uniform distribution calculated, between calculations code) differ about 17%.